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Tapentadol SR is an S8 scheduled (controlled) drug indicated for the management of moderate to severe chronic pain unresponsive to non-opioid analgesia. Tapentadol SR may be another option for people with chronic, severe disabling pain for whom non-opioid analgesics provide insufficient pain relief, and for whom a trial of opioids as an alternative is indicated. Addiction, Abuse, and Misuse: Tapentadol oral tablets or extended-release tablets expose users to risks of addiction, abuse, and misuse, which can lead to overdose. Assess patient’s risk before prescribing and monitor regularly for these behaviors and conditions. To ensure that the benefits of opioid analgesics outweigh the risks of addiction, abuse, and misuse, the Food and Drug Administration (FDA) has required a Risk Evaluation and Mitigation Strategy for these products.

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Tapentadol is a powerful analgesic that provides relief from moderate to severe pain. Tapentadol works by inhibiting the reuptake of norepinephrine, serotonin and dopamine in the brain. This allows tapentadol to have a strong anti-depressant effect as well. tapentadol can also be used as adjuvant therapy for patients with chronic musculoskeletal pain who are not responding adequately to treatment with non-opioid analgesics or antidepressants alone. tapentadol has been approved for use in Europe since 1997 and was approved in America only recently, under the trade name Nucynta (tapentadol).

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