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Research that has been conducted on mice has shown some validity in possibly using the drug for treating the symptoms of depression, however, the doctors do not believe that it can be used as an anti-depressant unless it is needed in such cases when the other depression meds that are given have failed.

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Tapentadol SR is an S8 scheduled (controlled) drug indicated for the management of moderate to severe chronic pain unresponsive to non-opioid analgesia. Tapentadol SR may be another option for people with chronic, severe disabling pain for whom non-opioid analgesics provide insufficient pain relief, and for whom a trial of opioids as an alternative is indicated. Addiction, Abuse, and Misuse: Tapentadol oral tablets or extended-release tablets expose users to risks of addiction, abuse, and misuse, which can lead to overdose. Assess patient’s risk before prescribing and monitor regularly for these behaviors and conditions. To ensure that the benefits of opioid analgesics outweigh the risks of addiction, abuse, and misuse, the Food and Drug Administration (FDA) has required a Risk Evaluation and Mitigation Strategy for these products.

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It is available in both immediate-release and extended-release oral tablets. Tapentadol extended-release can also be prescribed to treat severe neuropathic pain associated with diabetic peripheral neuropathy. Tapentadol may be prescribed when alternative pain treatments fail to provide any relief. Immediate-release tapentadol tablets are used to treat acute pain. Extended-release tapentadol tablets are prescribed to provide 24-hour chronic pain relief and should not be used on an as-needed basis for pain. Tapentadol works best if taken at the onset of pain; it may not work as well if pain levels are already high. Tapentadol should only be taken as prescribed.

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